C. O. Onyeji
Professor
B. Pharm., M.Sc., Ph.D. (Ife), MPSN

Email: cyponyeji@yahoo.com, conyeji@oauife.edu.ng

AREA OF SPECIALIZATION
Pharmacokinetics


 

RESEARCH INTEREST:

1. Drug-drug pharmacokinetics interaction studies with anti-infective agents

2. Effects of physiological and disease states on the disposition kinetics of antimalarial drugs

3. Bioavailability investigations after rectal drug administration

4. Studies on pharmacokinetics and enhancement of efficacy of anti-infective agents through liposomal formulations or combination therapy with immunomodulators.

5. Pharmacokinetic- Pharmacodynamic relations studies on anti-infective agents
 

SELECTED PUBLICATIONS:

Bassi PU, Onyeji CO, Ukponmwan O (2004). Effects of tetracycline on the pharmacokinetics of halofantrine in healthy volunteers. Br J. Clin Pharmacol., 58: 52–55.

Chukwuani CM, Bolaji OO, Onyeji CO, Makinde ON, Ogunbona FA,.(2004) Evidence for increased metabolism of chloroquine during the early third trimester of human pregnancy. Trop. Med. Int. Health, 9(5): 601–605.

Onyeji CO, Ogunbona FA (2001). Pharmacokinetics aspects of chloroquine-induced pruritus: Evidence for varied extent of metabolism of the drug. Eur. J Pharm Sci., 13: 195-201.

Onyeji CO, Nicolau DP, Nightingale CH, Bow L (2000). Modulation of efficacies and pharmacokinetics of antibiotics by granulocyte colony-stimulating factor in neutropenic mice with multidrug-resistant Enterococcus faecalis infection. J Antimicrob Chemother, 46: 429-436.

Nicolau DP, Onyeji CO, Zhong M, Tessier PR, Banevicius M, Nightingale CH (2000). Pharmacodynamics assessment of cefprozil against Streptococcus pneumoniae: Implications for breakpoint determination. Antimicrob Agents Chemother, 44(3): 1291-1295.

Onyeji CO, Adebayo AS, Babalola CP (1999). Effects of absorption enhancers in chloroquine suppository formulations: in vitro release characteristics. Eur J. Pharm Sci, 9: 131–136.

Onyeji CO, Tessier PR, Nightingale CH, Vallee F, Nicolau DP (1999). Pharmacokinetics of ticlopidine in the rabbit. J. Pharm Pharmacol., 51: 393–396.

Aideloje SO, Onyeji CO, Ugwu NC (1998). Altered pharmacokinetics of halofantrine by an antacid, magnesium carbonate. Eur J Pharmaceutics Biopharmaceutics, 46: 299-303.