Dr E. O. Iwalewa
Senior Lecturer
B.Sc., M.Sc. (Ibadan), Ph.D. (ABU)

Email: eoiwalewa@yahoo.com

AREA OF SPECIALIZATION
Natural Products activities in malarial infection and Inflammatory reactions, Neuropharmacology and Toxicology


 

RESEARCH INTEREST:

1. Ethnopharmacology: Identification of phytochemical constituents and Pharmacological Properties of Medicinal plants used as traditional medicine remedies in Malaria and Inflammatory reactions in particular which could be caused by various factors like: infections, pain, cell membrane integrity and free radical generation in disease conditions.

2. Malaria: (i) Evaluation of the sensitivity of human and rodent malaria parasites to chemotherapeutic agents using synthetic drugs and medicinal plant materials. (ii) Evaluation of the Determinant factors in resistant malarial parasites (in-vitro), using a continuous culture procedure.

3.  
4. Neuropharmacology and Toxicology: Examining the behavioural (CNS) effects of natural/medicinal plant products and evaluating the safety, signs and symptoms of acute and chronic toxicity of constitutents or substances from natural (both plants and animals) sources.
 

SELECTED PUBLICATIONS:

Iwalewa EO, A.A.Elujoba AA, Bankole OA (2005) In-vitro spasmolytic effect of aquoeus extract of Calotropis procera (leaf and stem) on guinea-pig trachea smooth muscle chain. Fitoterapia 76 (2): 250-253.

Ayoka AO, Akomolafe RO, Iwalewa EO, Ukponmwan OE (2005) Studies on the anxiolytic effect of Spondias mombin L. (Anacardiaceae) extracts. African. Journal of Traditional, Complementary and Alternative Medicine, 2 (2): 153–165.

Onayade OA; Iwalewa EO; Adamolekun B, Omobuwajo OR (2004) Behavioural effects and toxicity potentials of non-polar and polar extracts of Anaphe venata larvae in mice. Hamdard Medicus, XLVII (3): 153–156.

Akanmu MA, Iwalewa EO; Elujoba AA, Adelusola KA (2004) Toxicity potentials of Cassia fistula fruits as laxative with reference to Senna. African Journal of Biomedical Research, 7 (1): 23-26.

Orafidiya LO, Agbani EO; Iwalewa EO, Adelusola KA; Oyedapo OO. (2004) Studies on the acute and sub-chronic toxicity of the essential oil of Ocimum gratissimum Linn leaf.. Phytomedicine, 11 (1): 71-76.

Akomolafe RO, Adeoshun IO; Elujoba AA, Ayoka AO, Iwalewa EO (2004) An in-vitro study of the effect of Cassia podocarpa fruits on the intestinal motility of rats. Phytomedicine, 11 (2-3): 249-254.

Iwalewa EO, Agbani EO (2004) Effect of autacoid inhibitors and of an antagonist on malaria infection in mice. Brazilian Journal of Medical and Biological Research, 37 (8): 1199-1204.

Akomolafe RO, Adeoshun IO; Elujoba AA, Iwalewa EO, Ayoka AO (2004) Effects of Cassia podocarpa leaves extracts on rat ileum and colon.(in vitro). Bulletins of Latin American and Carrebean Medicinal and Aromatic Plants, 3 (3): 52–57.

Orafidiya LO, Agbani EO, Adelusola KA, Iwalewa EO, Adebanji OA, Adediran EAF, Agbani NT (2004) A study on the effect of the essential oil of Ocimun gratissimum Linn. on cyclophosphamide induced inhibited hair growth in pulp rats. International Journal of Aromatherapy, 14 (3): 119-128.

Omisore NOA, Adewunmi CO, Iwalewa EO, Ngadjui BT, Abegaz BM, Watchueng J, Ojewole JAO. (2004) Antinociceptive and anti-inflammatory effects of Dorstenia barteri (leaves and twigs) extracts in mice. Journal of Ethnopharmacology, 95 (1): 7-12.

Oyedapo OA, Adewunmi CO, Makanju VO, Iwalewa EO, Adenowo TK (2004) Anti-trichomonal activities of synthetic 1,3-diaryl-2-propen-1-ones on Trichomonas gallinae. African. Journal of Traditional, Complementary and Alternative Medicine, 1 (1): 55–62.

Fadeyi OO, Obafemi CA, Adewunmi CO, Iwalewa EO (2004) Antipyretic, analgesic, anti-inflammatory and cytotoxicity effects of four derivatives of acetylsalicylic acid and anthranilic acid in mice and rats. African Journal of Biotechnology, 3 (8): 426–431.

Adebajo AC, Olayiwola G, Verspohl JE, Iwalewa EO, Omisore NOA, Bergenthal D, Kumar V, AdesinaSK (2004) Evaluation of the ethnomedical claims of Murraya koenigii. Pharmaceutical Biology, 42 (8): 610–620.

Olayiwola G, Iwalewa EO, OmobuwajoOR, Adebajo AC, Adeniyi AA, Verspohl JE (2004) Anti-diabetic potentials of Jatropha tanjorensis leaves. Nigerian Journal of Natural Products and Medicine, 8: 37–40.

Iwalewa OE, Iwalewa OJ, Adeboye JO (2003) Analgesic, antipyretic, anti-inflammatory activities of the chloroform, methanolic and ether extracts of Vernonia cinerea leaf. Journal of Ethnopharmacology, 86 (2-3): 229–234.

Isah AB, Ibrahim YKE, Iwalewa EO (2003) Evaluation of the Antimalarial properties and standardization of tablets of Azadirachta indica (Meliaceae) in mice. Phytotherapy Research, 17 (7): 807-810.

Akomolafe RO, Adeoshun IO; Elujoba AA, Iwalewa EO, Ayoka AO (2003) In-vitro effects of Cassia sieberiena leaves extracts on the intestinal motility of rats. African Journal of Biomedical Research, 6 (1) 141–145.