The Department of Haematology and immunology was created as a separate unit from the old Department of Chemical Pathology, Haematology and Immunology on the 1st of August 1983. It is now a component part of the Faculty of Basic Medical Sciences, one of the three Faculties in the College of Health Sciences.
Academic Programmes
The department undertakes academic programmes, including research and teaching in Haematology and Immunology. In the fourth year of training, medical and dental students undergo basic teaching in Haematology and Immunology as part of the integrated course in Pathology leading to the second professional MBChB degree examinations. During the course, students are subdivided into smaller groups of 15 –25 for the monthly practical and bedside-clinical teaching in Haematology. The Department holds joint clinical meetings with the sister departments of Chemical Pathology, Medical Microbiology & Parasitology and Morbid Anatomy & Forensic Medicine as well as the Department of Medicine in the Faculty of Clinical Sciences.
A two-week introductory course in Haematology for fresh Medical & Dental students.
Sixteen weeks of 2- hour lectures on Wednesday afternoon in General Haematology, incorporating topics on:
Red cells and their disorders (physiology, metabolism, anaemia, haemolytic disorders, including haemoglobinopathies and enzymopathies).
White cells and their pathology (normal physiology, quantitative abnormalities & the leukaemias).
Lymphomas and related disorders
Haemostasis and platelet physiology and abnormalities.
Blood transfusion (blood group physiology, donor recruitment, cross-matching, haemolytic diseases of the newborn and complication of blood)
Transfusion of blood and blood products.
iii. Four weekly block postings during which students are divided into smaller groups, usually 10 groups in all, each group rotating through every four weeks for:
Practical sessions (3-hour x 2 weekly) on Haemocytommetry, blood film interpretation, haemoglobin electrophoresis, coagulation screening tests and blood transfusion techniques.
Weekly ward rounds and clinics, each of 3-4 hours per week.
Immunology Teaching Programmes
Sixteen two-hour lectures to introduce students to Basic and Clinical Immunology.
Laboratory Practical sessions for three hours weekly for four weeks during the Haematology block postings and
A weekly 2- hour tutorial session for four weeks.
Postgraduate Studies
Proposals to resuscitate postgraduate programmes in Immunology and commence the same in Haematology are in the pipeline.
Research Activities
The following are currently being pursued in the Department:
Chromosomal abnormalities in Hematological Malignancies.
Antisickling effects of benzoic acids (in collaboration with the Department of Pharmacognosy).
Prenatal diagnosis and newborn screening of sickle cell anaemia (SCA).
The heart in sickle cell disorders (SCD).
Clinical trial of Ciklavit in SCA.
HLA types in SCD
Sero-epidemiology of HIV-1 & HIV-2 infections.
Management of HIV/AIDS in a resource limited setting.
Purification, characterization and applications of new lectins.
Trace elements in health and disease.
Tissue typing in renal transplantation.
CD4/CD8 counts in health and disease.
Haematological Parameters and Fibrinolytic changes contributing to AVN in SCA
Study of Association between Uterine fibroid and Deep Venous Thrombosis (DVT)
Fibrinolytic activities in Haematological Malignancies.
Service
All the Academic staff are consultants to the Teaching Hospital: (four Consultant Haematologists and one Consultant Immunologist). Members of the Department therefore take active part in patient (in- and out-patients) care in the hospital. The consultant Immunologist assists with the Renal Transplantation programme of the Institution.
Facilities
Office Space:
There is a general departmental office for the head of department and the administrative staff. Every academic staff and senior technical staff has a personal office but any additional academic staff may not be so privileged.
Laboratories:
The Multi-disciplinary laboratory (MDL) is used for routine students’ practical session
The Department also has the following specialized laboratories:
Tissue culture/Cytogenetic laboratory
Immunology Laboratory
The very poorly equipped special Haematology laboratory.
Equipment:
Basic and specialized equipment are available, although a lot of the specialized equipment is in disrepair.
KEEP IN-VIEW PROGRAMMES
Introduction of new postgraduate programmes and resuscitating existing ones including Diploma courses, MSc and PhD in Haematology and Immunology.
Public enlightenment programmes on Sickle Cell Disorders and common haematological malignancies in this environment.
Consultant Services to the community through the OAU Health Centre.
Provision of more specialized laboratory services.
ACADEMIC STAFF CURRICULUM VITAE
i. Professor Durosinmi Muheez Alani MBBS (1978); FMCPath; FWACP (Lab. Med.).
Present Status: Professor in Haematology (OAU) and Consultant Haematologist, Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife
Fellowship Awards:
Commonwealth Medical Fellow in Haemato-Oncology and Cytogenetics, Haematology and Cytogenetics Department, Royal Marsden Hospital, London. 1994-1995.
PUBLICATIONS:
Thesis:
Studies on Protection from the Effects of the Carcinogen 7, 12-Dimthylbenz (A) Anthracene in Rat, FMCPath (Nig), 1985.
Published Articles:
Inglis G, Fraser RB, Durosinimi MA, Mackie A and Mitchell R, (1985) The potentiation of incomplete mouse monoclonal anti-Lea with colloids Transfusion 25 (4): 355-359
Williams CKO, Olofin AA, and Durosinmi MA (1986) Haemoglobinuric episodes following vigorous ritual dancing. E Afr Med J 63 (3): 182 -186
Durosinmi MA, Lawoyin DO, Ogunseyide AO, Avoseh MA, Williams CKO and Daramola JO (1987) Osteopetrosis in a Nigerian woman: A case report Afr J Med med Sci 16: 141-146.
Durosinmi MA, Olatunji PO, Falusi AG and Esan GJF (1989) Sickle cell anaemia in a 60-year old Nigerian West Afr J M 8(2): 139-142.
Durosinmi MA, Ogunseyinde AO, Olatunji PO and Esan GJF (1989) Prevalence of cholelithiasis in Nigerians with sickle cell disease Afr J Med med Sci 18: 223-227.
Durosinmi MA, Nwosu SO, Ogunniyi JO, Dada O and Okunlola MA (1989) Hodgkin's disease in siblings: A case report Afr J Med med Sci 18: 219-222.
Alabi ZO and Durosinmi MA (1989) Leg-calve Perthe's disease associated with chronic myeloid leukaemia in a child: A case report E Afr Med J 66(8): 556-559.
Osoba, OA, Adesanya SA and Durosinmi MA (1989) Effect of Zanthoxylum xanthoxyloides and some substituted benzoic acids on Glucose-6-phosphate and 6-phosphogluconate dehydrogenases in HBSS red blood cells J Ethnopharmacology 27: 177-183.
Adekile AD, Okonofua FE and Durosinmi MA (1990) Characteristics of menstruation in Nigerian with patients with HBSS NMJ 27: 177-183.
Durosinmi MA, Badejo OA, Ayoade MA and Odelana CO (1990) Essential thrombocythaemia associated with priapism: A case report E Afr Med J 67 (8): 594-595.
Durosinmi MA, Adejuyigbe O, Adamolekun B, Adekile AD an Odunusi EO (1991) Variegate (mixed) porphyria in a Nigerian girl Ann Trop Paedtri 11: 95-98.
Owa JA, Durosinmi MA and Alabi OA (1991) Determinants of severity of neonatal hyperbilirubinaemia in ABO incompatibility in Nigeria Trop Doctor 21: 19-22.
Lawal OO, Ojo OS and Durosinmi MA (1990) Burkitt's lymphoma in a 45-year old Nigerian woman Trop Geor Med 42: 294-297.
Durosinmi MA, Faluyi JO and Ogunsanwo BA (1993) Chromosomal aberrations in Nigerians with haematological malignancies: Preliminary report Afr J Med med Sci 22: 21-27.
Durosinmi MA, Gevao SM and Esan GJF (1991) Chronic leg ulcers in sickle disease: Experience in Ibadan Nigeria Afr J Med med Sci 20: 11-14.
Durosinmi MA, Ndububa DA, Alabi OA and Soyinka OO (1991) Prevalence of HIV-1 and HBsAg in normal blood donors inIle-Ife, Nigeria NMJ 21 (5): 138-140.
Durosinmi MA, Ojo JO, Oluwole AF, Akanle OA, Arshed W and Spyrou NM (1993) Trace elements in SCD J Radioanalytical Nucl Chem 168 (1): 233-242.
Ogunsola JO, Oluwole AF, Asubiojo OI, Durosinmi MA, Fatusi AO and Ruck W (1994) Environmental impact of vehicular traffic in Nigeria: Health aspects. Sci Total Environ 146/147:111-116.
Durosinmi MA, Adekile AD, Ogunsanwo BA et al (1993) Trace elements in Nigeria with SCD (HBSS) NMJ 24 (3): 94-96
Adamolekun B, Durosinmi MA, Olowu W and Adediran I (1993) Prevalence and classification of epileptic seizures in Nigerians with sickle cell anaemia J Trop Med Hyg 96: 288-290
Durosinmi MA and Ajayi AA (1993) A prospective study of chloramphenicol induced plastic anaemia in Nigerians Trop Geor Med 45 (4): 159-161.
Durosinmi MA and Alabi OA (1994) Disputed paternity: Experience in Ile-Ife Nigeria West Afr J Med 14(2): 88-90.
Durosinmi MA and Adediran I (1993) Management of cancer under structural adjustment programme (SAP): Experience in Ile-Ife Nigeria NMJ 25(3): 92-96.
Durosinmi MA, Ojo JO, Oluwole AF, Ononye AF, Akanle OA and Spyrou NM (1994) Elemental concentrations in Nigerians with affective disorders using proton-induced X-ray emission. Biol Trace Element Res 43/44:357- 362
Durosinmi MA, Ojo JO, Oluwole AF, Akanle OA and Spyrou NM (1994) Study of trace elements in blood of cancer patients by proton-induced X-ray emission. Biol Trace Element Res 43/44: 351-356.
Ojo JO, Oluwole AF, Durosinmi MA, Ogunsola OJ, Akanle OA and Spyrou NM (1994) Baseline levels of elemental concentrations in whole blood, plasma and erythrocytes of Nigerian subjects. Biol Trace Element Res 43/44: 461- 470.
Oluwole AF, Ojo JO, Durosinmi MA, Asubiojo OI, Akanle OA, Spyrou NM and Filby RH (1994) Elemental composition of head hair and finger nails of Nigerian subjects. Biol Trace Element Res 43/44: 443-452
Ojo JO, Oluwole AF, Durosinmi MA, Asubiojo OI, Akanle OA and Spyrou NM (1994) Correlations between trace element levels in head hair and blood components of Nigerian subjects Biol Trace Element Res 43/44: 453-459.
Durosinmi MA, Odebiyi I, Adediran I and Akinola NO (1995) Acceptability of prenatal diagnosis of SCA by female patients and some parents of SCA patients in Nigeria Social Sci Med 41 (3): 433-436.
Olowu WA, Taiwo O, Oyelami OA, Durosinmi MA, Adeodu OO, Akinsola A and Ogundipe MO (1995) Renal tubular handling of sodium in Nigerian children with homozygous sickle cell disease. The N Postgrad Med J 2(2): 44-48
Adelusola KA, Odesanmi WO, Adejuyigbe O, Rufai OA, Durosinmi MA, Akinola NO (1995) Malignant solid tumours in Nigerian children. Central Afr J Med 41(10):322-326.
Alemnji GA, Thomas KD, Durosinmi MA, Taiwo OO and Fakunle JB (1995) Haematogram and serum iron status of Nigerian children with protein-energy malnutrition. East Afr Med J 72(9): 605-608.
Ojo OS, Thursz M, Thomas HC, Ndububa DA, Adeodu OO, Rotimi O, Lawal AA, Durosinmi MA, Akonai AK, Fatusi AO and Goldin RD (1995) Hepatitis B virus markers, hepatitis D virus antigen and hepatitis C virus antibodies in Nigerian patients with chronic liver disease. East Afr Med J 72:32-34.
Durosinmi MA, Matutes E, Ryan K, Nathwani A, Hedges M and Catovsky D (1996) An elderly man with weight loss and anaemia. Leukemia and lymphoma 23:181-183.
Ojo JO, Oluwole AF, Durosinmi MA and Asubiojo OI (1996) Regulation of elemental ratios in affective disorders: A study using PIXE Nucl Instr & Meth in Phys Res B 117: 175-178.
Ogboko VI, Hdukwe KC, Adelusola K and Durosinmi MA. Burkitt's lymphoma presenting as lower lip paraesthesia in a 24-year old Nigerian. Case report. Austral Dent J. Accepted 9/3/97 (MS 420).
Durosinmi MA, Odebiyi AI, Akinola NO, Adediran IA, Aken'ova Y, Okunade MA, Halim NK, Onwukeme KE, Olatunji PO and Adegoroye DE (1996) Acceptability of prenatal diagnosis of sickle cell anaemia by a sample of Nigerian population. Afr J Med med Sci (accepted 24/3/96).
Selo-Ojeme DO, Onwudiegwu U, Durosinmi MA and Owolabi AT (1997) Emergency autologous transfusion in the management of ruptured ectopic pregnancy. J Obst. Gynaecol.
Aghanwa HS, Akinola NO, Fadiran OA, Salawu L and Durosinmi MA (1997) Polysubstance dependence, a psychosocial complication of sickle cell anaemia in a female adult Nigerian: A case report Nig Med J 1997, 32: 27-29
Adediran, IA., Durosinmi, MA., Ogunniyi, SO., Akinola, NO., Akanmu, AS. (1999) Haemostatic Parameters in Normal Pregnant Nigerians and Nigerians with Hypertensive Disorders of Pregnancy. The Nigerian Postgraduate Medical Journal, 6: 49 - 52
Akinsola, A., Durosinmi, MO., Akinola, NO. (2000) The haematological profile of Nigerians with chronic renal failure. African Journal of Medicine and Medical Sciences, 29: 13-16
Okanny, CC., Durosinmi, MO., Chukwuani, CM., Njoku, OS. Akinola, NO., Herrada, SC., Ogbe, OP., Onwukeme, KE..Faluyi, JO, Akanmu, AS., Akinsete, I. (2000) Interferon alfa-2a (Roferon R –A) monotherapy in chronic myelogenous leukaemia: A pilot study in Nigerian patients in early chronic phase. West African Journal of Medicine, 19 (4): 286-292
Ndububa DA, Ojo OS, Adeodu OO, Adetiloye VA, Olasode BJ, Famurewa OC, Durosinmi MA and Agbakwuru AE (2001) Primary hepatocellular carcinoma in Ile-Ife, Nigeria: A prospective study of 154 cases. N JM 10(2): 59-63
Salawu L and Durosinmi MA(2001) Immune thrombocytopaenic purpura: in Ile-Ife, Nigeria. Afr J Med. Med. Sci. 30:99-103
Salawu L, Olaomi OO, Paul-Odo B, Olayinka OS, Durosinmi MA. (2001) Aspirin-induced duodenal perforation in a Nigerian with sickle cell disease: a case report. Niger Postgrad Med J., Jun;8(2):90-2
Salawu L and Durosinmi MA(2002) Autoimmune haemolytic anaemia: pattern of presentation and management outcome in a Nigerian population: a ten-year experience. Afr J Med. Med. Sci., 31:97100
Olowu WA, Taiwo O, Oyelami A, Durosinmi MA, Adeodu OO, Akinsola A, Ogundipe MO. (2002) Glomerular filtration rate in Nigerian children with homozygous sickle cell disease. Niger J Med., Jan-Mar; 11(1):23-5
Salawu L and Durosinmi MA. Autoimmune haemolytic anaemia: pattern of presentation and management outcome in a Nigerian population: a ten-year experience. African Journal of Medicine and Medical Sciences 2002, 31: 97-100
Current Research Activities:
Chromosomal aberrations in Haematological Malignancies
Haematological Malignancies: Epidemiology and Management
Trace elements in health and disease
Anticoagulant Properties of Occimum gratisimum leaf
Prenatal Diagnosis of Sickle Cell Disorders
ii. Dr. Togun Rachel Adetoro (Mrs) Bsc (1974); MSc; PhD ( Ife).
Present Status: Senior Lecturer in Immunology (OAU) and Consultant Immunologist, Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife
Fellowship Awards:
Oyo State ( Nigeria) Postgraduate Fellowship, University of Manchester, 1978-1980.
Sir Adam Thompson/British Caledonian Airways Fellowship, University of Sussex, 1986.
Fellow of the Medical Research Council of Canada, Wellesley Central Hospital, University of Toronto, Ontario, Canada, 1996.
Publications:
Theses:
Development of an enzyme-linked immunoassay for Rheumatoid Factor, MSc, 1980.
Galactose-binding lectins from Telfairia occidentalis (hook. F) (cucurbitaceae) and Tetracarpidium conophorum (Null. Arg., Hutch and Dalz) Euphorbiaceae). PhD, 1990.
Published Articles:
Togun RA and Brenchley P (1983) Some factors affecting the quantitation of rheumatoid factors by enzyme immunoassay. J Immuno Methods 65:343-350.
Togun RA , Animashaun T and Kay JE (1987) A lectin from Artoocarpus communis mitogenic for T. Lymphocytes. Biochem Soc Transac 15:843-844
Togun RA , Animashaun T, Benzie FR and Kay JE (1988) Purification and characterization of a mitogenic Lactose-binding lectin from Tetracarpidium conophorum seeds. In Lectins, Biology, Biochemistry, Clinical Biochemistry 6:369-372.
Animashaun T, Togun RA and Kay JE (1989) Purification and characterization of a mitogenic Galactose-binding lectin from Tetracarpidium conophorum seeds. J Cellular Biochem Suppl 13A:117.
Togun RA and Brenchley P (1990) Enzyme immunoassay of IgM and IgG rheumatoid factors. West Afr Pharm 4:33-37.
Togun RA , Animashaun T, Kay JE and Aboderin AA (1994) A Galactose-binding T-cell mitogenic lectin from the seeds of Telfaria occidentalis. Phytochem 35 (5):1125-1130.
Animashaun T, Togun RA andHughes RC (1994) Characterization of isolectins in Tetracarpidium conophorum seeds. ( Nigeria walnut). Glycoconjugate J 11 (4):299-303.
Togun RA, Binutu OO, Animashaun T and Aboderin A (1994) Beta-Galactoside binding lectins from the seeds of Tetracarpidium conophorum (Euphorbiaceae). Nig J Bioche. 9:17-25.
Adeyemi A, Togun RA, Ogunbiyi OA and Aboderin A (1995) Some properties of the haemaglutinins from the seeds of Dioclea reflexa (Hook, F) (Papilionaceae) Nig J Biochem. 9:26-36.
Resetkova E, Kawai K, Enomoto T, Arreaza G, Togun RA, Foy TM, Noelle RJ and Volpe R, (1996) Antibody to gp 39, the ligand for CD40 significantly inhibits the human response from Grave's thyroid tissue xenografted into severe combined immunodeficient (SCID) mice. Thyroid 6 (4): 267-273.
Togun RA, Resetkova, E, Kawai K, Enomoto T and Volpe R (1997) Activation of CD8+ T lymphocytes in insulin-dependent diabetes mellitus. Cli Immunol Immunopathol 82(3): 2443-249.
Ajomale OO, Binutu OO, Togun RA and Aboderin A (1997) A galactose binding lectin from the seeds of Caesalpinia bonduc (Linn. roxb (Caesaipiniaceae). Nig J Biochem Mol Biol (In Press)
Current Research Activities:
Isolation and characterization of new lectins from tropical plants.
Immunopathology of autoimmune diseases.
iii. Dr. Akinola Norah Olubunmi (Mrs.) BSc; (Hons); MB ChB (1981); Dip in Haem.
Present Status: Reader in Haematology (OAU) and Consultant Haematologist Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife
Fellowship Awards:
Research Fellowship Award of the Wellcome Trust Fund in Sickle Cell Rheology, University of Birmingham Medical School, Birmingham, UK 1990-1991
Publications:
Theses:
The Role of Adrenergic and Cholinergic Mechanisms in Endotoxin-Induced Fever in Non-Anaesthetized Rats, BSc (Health Sciences) 1978.
The Preparation of Infant Formula, MB ChB (Community Health) 1981.
Inhibition of CFU-GM Proliferation by a New Cell Line (CL-I) Compared with K562 and HL-60, DCH, 1989.
Rheology of Vascular Occlusion in Sickle Cell Anaemia, PhD (Haematology) 1992.
Some observations in the Cardiovascular Status of Nigerian Individuals with Sickle Cell Anaemia at rest and in response to exercise, FMCP (Nig) 1994.
Boarding School Anaemia – Does it exist? FMCPath (Nig) 1998
Published Articles:
Elegbe IA, Ojofeitimi EO, Elegbe I and Akinola NO (1982) Pathogenic bacteria isolated from infant feeding teats. Amer J Dis Child 136: 672-674.
Andy JJ, Ladipo GOA, Owolabi SP, Teniola SO, Ajayi AA, Akinola NO and Morakinyo O (1985) Blood pressure Distribution of Nigerians in the first two decades of life. Ann Trop Paedtr 5:113-118.
Akinola NO, Stevens SME, Franklin IM, Nash GB and Stuart J (1992) Rheological changes in the prodromal and established phases of sickle cell vaso-occlusive crisis. Br J Haematol 45:902-906.
Akinola, NO., Stevens, SME., Franklin, IM., Nash, GB., Stuart, J. (1992) Subclinical Ischaemic Episodes during the Steady State of Sickle Cell Anaemia. Journal of Clinical Pathology, 45: 902-906
Stuart J, Stone PCW, Akinola NO, Imore JR and Pepys MB (1994) Monitoring the acute phase response to vaso-occlusive crisis in sickle cell disease. J Clin Pathol 47: 166-169.
Durosinmi MA, Odebiyi I, Adediran I and Akinola NO (1995) Acceptability of prenatal dignosis of SCA by female patients and some parents of SCA patients in Nigeria Social Sci Med 41 (3): 433-436.
Adelusola KA, Odesanmi WO, Adejuyigbe O, Rufai OA, Durosinmi MA, Akinola NO (1995) Malignant solid tumours in Nigerian children. Central Afr J Med 41(10):322-326.
Akinola NO. (1996) The liver biopsy procedure, indications, technique and pitfalls. Dokita, 23: 44-45
Durosinmi MA, Odebiyi AI, Akinola NO, Adediran IA, Aken'ova Y, Okunade MA, Halim NK, Onwukeme KE, Olatunji PO and Adegoroye DE (1997) Acceptability of prenatal diagnosis of sickle cell anaemia by a sample of Nigerian population. Afr J Med Med Sci., 26: 55-58
Aghanwa, SH., Akinola, NO., Fadiran, OA. (1997) Dependence Syndrome, a Psychosocial Complication of Sickle Cell Anaemia in a Female Adult Nigerian: A Case Report. Nigerian Medical Journal, 32: 27-29
Adediran, IA., Durosinmi, MA., Ogunniyi, SO., Akinola, NO., Akanmu, AS. (1999) Haemostatic Parameters in Normal Pregnant Nigerians and Nigerians with Hypertensive Disorders of Pregnancy. The Nigerian Postgraduate Medical Journal, 6: 49 - 52
Akinsola, A., Durosinmi, MO., Akinola, NO. (2000) The haematological profile of Nigerians with chronic renal failure. African Journal of Medicine and Medical Sciences, 29: 13-16
Okanny, CC., Durosinmi, MO., Chukwuani, CM., Njoku, OS., Akinola, NO.,Herrada, SC., Ogbe, OP., Onwukeme, KE., Faluyi, JO., Akanmu, AS., Akinsete, I. (2000) Interferon alfa-2a (Roferon R –A) monotherapy in chronic myelogenous leukaemia: A pilot study in Nigerian patients in early chronic phase. West African Journal of Medicine, 19 (4): 286-292
Ikem, RT., Akinola, NO., Balogun, MO., Ohwovoriole, AE., Akinsola, A. (2001) What does the presence of Hypertension portend in the Nigerian with Non-Insulin Dependent Diabetes Mellitus? West African Journal of Medicine, 20: 127-130
Adebayo, RA., Balogun, MO., Akinola, NO. (2002) Cardiovascular changes in sickle cell anaemia. Nigerian Journal of Medicine, 11(4): 145-152
Adebayo, RA., Balogun, MO., Akinola, NO. (2002) The clinical, electrocardiographic and self-paced walking exercise features of Nigerians with Sickle cell anaemia presenting at OAUTHC, Ile-Ife. Nigerian Journal of Medicine, 11(4): 170-176
Current Research Activities:
The heart in Sickle Cell Disorders
Coagulation Abnormalities in Chronic Renal Failure
Prenatal Diagnosis and Newborn Screening for Sickle Cell Anaemia
Haemostatic disorders.
Coagulation Abnormalities in Chronic Renal Failure
HIV/AIDS
CD4/CD8 in health and disease
HLA types in Sickle cell disorders
iv. Dr. Adediran Ismail Adetunji MB BS (1987); FMCPath (Nig).
Present Status: Lecturer I
Publications:
a. Thesis:
Some haemostatic parameters in pregnancy-related hypertension. Part II FMCPath (1996).
b. Published Articles:
Adamolekun B, Durosinmi MA, Olowu W and Adediran I (1993) Prevalence and classification of epileptic seizures in Nigerians with sickle cell anaemia J Trop Med Hyg 96: 288-290
Durosinmi MA and Adediran I (1993) Management of cancer under structural adjustment programme (SAP): Experience in Ile-Ife Nigeria NMJ 25(3): 92-96.
Durosinmi MA, Odebiyi I, Adediran I and Akinola NO (1995) Acceptability of prenatal diagnosis of SCA by female patients and some parents of SCA patients in Nigeria Social Sci Med 41 (3): 433-436.
Durosinmi MA, Odebiyi AI, Akinola NO, Adediran IA, Aken'ova Y, Okunade MA, Halim NK, Onwukeme KE, Olatunji PO and Adegoroye DE (1996) Acceptability of prenatal diagnosis of sickle cell anaemia by a sample of Nigerian population. Afr J Med med Sci (accepted 24/03/96).
Adediran IA, Durosinmi MA, Ogunniyi SO, Akinola NO and Akanmu AS (1999). Haemostatic parameters in normal pregnant Nigerians and Nigerians with hypertensive disorders of pregnancy. Nig. Post-graduate Med. J. 1999 vol 6 (2): 49-52.
Adediran IA, Adejuyigbe EA, Oninle SO. Haematological profile and malaria parasitaemia in Nigerian children requiring emergency blood transfusion. Nig. Med J.
Ismail A. Adediran and Muheez A Durosinmi Peripheral blood and Bone Marrow changes in patients with Acquired Immunodeficiency syndrome
SUBMITTED FOR PUBLICATION
Priapism in a South Western Nigeria Teaching Hospital: A Ten Year review.
Prognostic Indices and Survival Determinants in Chronic Myeloid Leukaemia.
Prognostic Indices and Survival Determinants in Burkitt’s lymphoma.
Managing Acquired Immunodeficiency Syndrome (AIDS) in a poor: Economy. A Six-Year Experience from a Nigeria Tertiary Hospital.
Fibrinolytic activity in Nigerian Diabetics.
CURRENT RESEARCH ACTIVITIES
Haematological Parameters in unfit intending Blood Donors rejected on account of anaemia and or Microfilaria.
Fibrinolytic activity in patients with Benign Prostatic Hypertrophy and Effect of Prostatectomy.
ABO Blood Group Antibody Titres in HIV/AIDS
v. Dr. Salawu Lateef BSc; (Hons); MB.ChB (1987); FWACP (Lab. Med.);
FMC Path
Present Status: Lecturer I
Publications:
Thesis/Dissertation:
Age, sex and seasonal variation in the occurrence of Tuberculosis in Ile-Ife (1976-1980): presented to the Faculty of Health Sciences, OAU Ile-Ife, for the award of BSc (Health sciences) degree in 1984.
Prevalence of Schizophrenia in Ile-Ife presented to the Faculty of Health Sciences, OAU Ile-Ife, for the award of MB Ch.B degree in 1987.
ESR and plasma viscosity in health and disease in Nigerians: presented to the West African Postgraduate Medical College for postgraduate fellowship award (Laboratory Medicine) in April 1998.
Study of relationship between HbF level, some haematologial indices and persistent splenomegaly in Nigerians with sickle cell anaemia: presented to the National Postgraduate Medical College of Nigeria for the award of postgraduate fellowship (Haematology) in May 1998.
Serum immunoglobulins classes (IgG, IgA and IgM) and acute phase proteins (Transferrin. Alpha2-macroglobulin and Haptoglobin) in pregnant Nigerian women with urinary schistosomiasis to be presented to the Faculty of Basic Medical Sciences of the College of Medicine, University of Ibadan in August, 2003
b. Published Articles:
Elegbe IA, Salawu L, Adeyemo AO Pulmonary Tuberculosis in Nigerians Journal of the Royal Society of Health 1986; 2: 69-71
Fagade OO, Salawu L, owotade FJ, David-West B, Durosinmi MA, Osteomyselitis of the mandible in a Nigerian with sickle cell Hubs disease: a case report. The Nigerian Postgraduate Medical Journal 1997; 4:25-26
Salawu L, Durosinmi MA, Erythrocyte sedimentation rate and plasma viscosity in health and disease Nigerian Journal of Medicine.2001; 10:11-13
Salawu L, Durosinmi MA, Immune thrombocytopaenic purpura: 11 year experience in Ile-Ife, Nigeria. African Journal of Medicine and Medical Sciences. 2001; 30:99-103
Salawu L, Olaomi OO, Paul-Odo B, Olayinka OS, Durosinmi MA, Aspirin-induced duodenal perforation in a Nigerian with sickle cell disease: a case report. The Nigerian Postgraduate Medical Journal 2001; 8:90-92
Salawu L, Durosinmi MA, Autoimmune haemolytic anaemia, pattern of presentation and management outcome in a Nigerian population: a ten-year experience. African Journal of Medicine and medical Sciences. 2002; 31: 97-100
REQUIREMENT
ADMISSION REQUIREMENTS
The minimum requirements for admission to the Bachelor of Medicine, Bachelor of Surgery (MBChB) degree programme are those for entry to the University.
Candidates may be admitted;
(i) through the Joint Matriculation Examination (JME) entrance
examination into Part I.
(ii) Through the General Certificate Advanced Level or equivalent
qualification by direct entry into Part II
PART I
Candidates must satisfy the University minimum requirements of five credits at the Ordinary Level, which must include Mathematics, Physics, Biology, Chemistry and English Language.
PART II
In addition to the University minimum requirements for admission, candidates must possess.
(i) Advanced Level in the General Certificate of Education or its equivalent.
The qualifying subjects must include good grades in Biology, Physics, and Chemistry.
OBJECTIVES
STAFF
Academic
IA Adediran MB.BS (1987); FMCPath (Senior Lecturer and Ag. Head of Department)
MA Durosinmi MBBS (1978); FMCPath; FWACP (Lab. Med.).
(Professor of Haematology)
NO Akinola (Mrs) BSc; MBChB (1981); Dip in Haem; PhD; FMCP; FMCPath.
FACP (Reader)
RA Togun (Mrs) BSc (1974); MSc; PhD (Senior Lecturer).
AO Adeloye (Mrs.) AIMLS (Assistant Chief Technologist)
FI Aboderin (Mrs.) AIMLS; FIMLS (Technologist I)
LO Akinyemi ANIST (Technologist I)
IO Owootomo ANIST (Technologist I)
J Adeyemo Laboratory Superintendent
S. Fasae Laboratory Attendant
Administrative
FM Adesida (Mrs.) Chief Typist/Secretary
O. Alo (Mrs.) Typist III
Staff Development/Recruitment
The department has a vacant academic establishment, preferably for Clinical
Immunologists. Members of staff have been enjoying some International Fellowships to undergo Specialized training outside the country.
COURSE OUTLINE
REVISED POSTGRADUATE PROGRAMMES IN IMMUNOLOGY
Preamble
Postgraduate programmes in Immunology, notably MSc and PhD, had been available in the then Faculty of Health Sciences in the eighties but became moribund for lack of facilities to conduct meaningful research. It has been resuscitated and an M.Phil programme has been included.
1. Introduction
Postgraduate programmes in Immunologyoffer a multidisciplinary approach to formal studies and research in Immunology at the Obafemi AwolowoUniversity, Ile-Ife. These multi-departmental and multi-faculty programmes are based in the Department of Haematology and Immunology, Faculty of Basic Medical Sciences, College of Health Sciences. Since Immunology is the basis of many diseases/disorders known to man and a tool used in recombinant DNA technology, a thorough understanding of this discipline is essential and should integrate other biological sciences such as, cell biology, molecular genetics, molecular biophysics, biochemistry, microbiology (virology), parasitology, haematology, pathology and clinical medicine.
2. Objectives
Immunology postgraduate programmes will provide fundamental knowledge and training in Immunology such that candidates will be enabled to teach the subject, conduct research and provide service in this area of clinical medicine. The candidate shall be capable of scientific analysis of the immune system, its genes and associated receptors and signals. The candidate shall also be able to interprete such results within formal/scientific and clinical settings.
These programmes shall therefore contribute to the work force of the nation by producing:
Teachers of Immunology;
Research scientists in immunochemistry and immunobiology; and
Clinical Immunologists capable of diagnostic laboratory services in serology, immunochemistry and immunobiology.
3. Degrees Offered
Master of Science (M.Sc) in Immunology;
Master of Philosophy (M.Phil) in Immunology; and
Doctor of Philosophy (Ph.D) in Immunology
Admission Requirements
M.Sc Programme
An applicant for M.Sc (Immunology) shall be a graduate of the Obafemi Awolowo University, Ile-Ife, or of any other approved university with a bachelor’s degree in a biomedical science e.g. Medicine, Biochemistry, Chemistry, Physiology, Anatomy, Pharmacy, Dentistry, Nursing, Microbiology, Haematology, Immunology, Public Health or Veterinary Medicine. The applicant shall normally possess at least a Second-Class (Lower Division) Honours degree or an equivalent unclassified degree to be eligible for admission.
B. M.Phil Programme
An applicant for M.Phil shall be a graduate of Obafemi Awolowo University or any other approved university
a) with a Bachelor’s Degree in a biomedical Science e.g. Medicine, Dentistry, Biochemistry, Chemistry, Anatomy, Physiology, Pharmacy, Nursing, Microbiology, Haematology, Immunology, Public Health or Veterinary Medicine. The applicant shall normally possess not less than a second class (Upper Division) Honours (or equivalent unclassified degree) to be eligible for admission.
b) a graduate of OAU or any other approved University with a Master’s Degree in Immunology or a related subject.
C. Ph.D. Programme
An applicant shall be a graduate of Obafemi Awolowo University or any other approved university and possess a Master’s Degree in Immunology or a related subject with a research thesis and a weighted coursework average which shall normally not be less than 60% (B+).
5. M.Sc. and M.Phil Programmes
M.Sc Programme
Minimum Requirements:
To qualify for an M.Sc. degree, the candidates shall be required to pass a total of 29 units of course work comprising 13 units of core courses (IMM 601, 605, 607, 617 and 623); and 6 units of approved elective courses. In addition he must carry our 6 units of a research thesis on any topic of interest. Each student’s plan of study and title of research must be accepted by his supervisor and recommended by the Faculty Postgraduate Committee to the Postgraduate College for approval. The total workload shall be 25 units.
M. Phil Programme
Minimum Requirements
Candidates with Master’s Degree in Immunology shall be required to take 6 units of relevant core courses as may be directed by the Board of Postgraduate College on recommendation of the Faculty Committee (see list of core courses below).
.
Candidates with Master’s Degree in related subjects shall be required to take all the core courses (13 units) in M.Sc (Immunology). The total workload shall be 30 units.
Courses offered:
Harmattan Semester (Core Courses)
Course Code Course Title Units
IMM 601 The Immune System 3
IMM 606 Cellular Immunology 3
IMM 607 Parasitism, Infection and Immunity 3
IMM 623 Immunochemistry 3
IMM 617 Current Topics in Immunobiology and Immunology 1
Total No. of Units 13
Rain Semester
Departmental (Sub-specialty) Elective Courses:
Course Code Course Title Units
IMM 606 Immunogenetics and Transplantation Immunology 2
IMM 615 Foundations of Mammalian Cell Culture 3
IMM 608 Molecular Approach to Immunology 3
IMM 610 Membrane Immunochemistry 3
IMM 612 Immunohaematology and Oncology 2
IMM 614 Immunological Diseases 2
Immunology (IMM) courses that are not core courses may be offered as sub-specialty electives, together with non-departmental courses in areas of interest as desired by the applicant. At least 3 units or at most 4 units of courses shall be offered from departmental elective courses above and at least a 2-unit course from non-departmental elective courses below.
B) Approved Non-Departmental Elective Courses:
Course Code Course Title Units
BCH 603 Advances in protein chemistry 3
BCH 606 Advanced molecular Biology 3
BCH 608 Biological membranes 2
BCH 609 Current Topics in Cellular Regulation 3
BOT 619 Advanced Cytogenetics 3
CHP 607 Nutrition and Metabolic Disorders 3
CHP 608 Clinical Enzymology 3
CLI 619 Advanced Haematology 3
MIC 611 Advanced Virology 3
MMP 600 Principles and Clinical Aspects of
Bacterial Infections 3
MMP 602 Principles and Clinical Aspects of
Virology 3
ZOO 618 Animal Cytogenetics 3
Total No. of Units for Elective Courses (A + B) = [3 (4) + 3 (2)] = 6.
Ph.D Programme
6.1Minimum Requirements are as stated in the handbook on the Regulations Governing Postgraduate Studies of the Postgraduate College.
7. Course Descriptions for Immunology Courses
IMM 601 - The Immune System 2-0-3, 3 Units
An advanced course stressing the central and fundamental concepts in modern immunology, structure, and biosynthesis of antibodies; antigenicity; antigen-antibody reactions; the specificityof immune reactions. The lymphocyte in immunity. Hypersensitivity; immunodeficiency and auto-immunity. Immunity to tumours; histocompatibility antigens.
IMM 605 – Cellular Immunology 1-1-3, 3 Units
A detailed study and analysis of cellular mechanisms in the immune system. T and B cell fractionation and identification. Functions of T and B cells. Lymphokines; macrophages; memory. Tolerance. Structure and function of lymphoid tissue. Cooperations in the immune response cytotoxic mechanisms. Delayed hypersensitivity.
IMM 606 - Immunogenetics and Transplantation Immunology 1-1-0, 2 Units
The genetics and fine structure of the major histocompatibility complex (MHC) loci. Transplantation and rejection. Histocompatibility antigens. GvH reactions. Modes of rejection. Immune response to tumors. Ir genes. Demonstration of tissue typing methodology.
IMM 607 – Parasitism, Infection and Immunity 1-1-3, 3 Units
A course dealing with microbial, protozoan and metazoan parasites of man and other animals, and the host cell responses to these Mechanisms of resistance; immunological consequences of parasitism and infection. Immunological methods in virology, bacteriology and parasitology.
IMM 608 – Molecular Approach to Immunology 1-1-3, 3 Units
Modern molecular probes for Immunobiology. A detailed study of the molecular structure and function of antibodies, and the evolution genetic basis of variation. Structure function relationships, the binding site. Ig genetic fine structure. Molecular basis for immune signals and their receptors. (Prerequisite: IMM 601)
IMM 610 – Membrane Immunochemistry 1-1-3, 3 Units
Immunochemical approaches to the determination of the structure and function of biological membranes. The lymphocyte membrane; membrane flow phenomena, capping patching, and their molecular bases. Immunochemical definition of membrane assembly. Immunoelectron microscopy of the cell membrane.
IMM 612 – Immunohaematology and Oncology 1- 0 - 3, 2 Units
A course dealing with the application of immunological methods and principles in haematology and oncology. Alloantibodies and haemolysis; lymphoid tissue systems; immunodeficiency and haematological cancers; immunotherapy in leukaemias; immunosuppression. Antibodies to platelets and white cells. Immunogenetics of human blood groups and transfusion therapies.
IMM 614 – Immunological Diseases 1-0-3, 2 Units
Alterations in T and B cell structure and functions in human disease states. In –appropriate immune responses. Immunological disease entities: diagnostic principles etiology: pathogenesis: animal models. Manipulation of the immune system.
IMM 616 – Foundations of Mammalian Cell Culture 1-1-3, 3 Units
The foundations and applications of mammalian cell and tissue culture. Establishment of differentiated cell lines. The use of culture technics to solve fundamental problems in cell and molecular biology, with special reference to applications to cells of the immune system.
IMM 617 – Current Topics in Immunobiology and Immunology 0-1-0, 1 unit
Seminars by student and staff on the most relevant contemporary issues in immunological sciences. Guest lecturers will be invited to participate.
IMM 623 – Immunochemistry 2-0-3, 3 Units
Preparation, purification and characterization of antigens and antibodies; complement biology and technology; immune complexes antigen antibody interactions; radioimmunoassay; immuno-fluorescence.
LIST OF STAFF WITHIN THE DEPARTMENT FOR THE POSTGRADUATE PROGRAMMES
S/No NAME QUALIFICATIONS STATUS SPECIALISATION
M.A. Durosinmi MBBS (Ibadan), FMCPath Professor Immuno-haematology, (Nig); FWACP (Nig) Tumour Immunology and Cytogenetics
